Sedative Effect of Midazolam Elixir Compare to Vial Through Oral Route in Uncooperative Pediatric Dental Patients
نویسندگان
چکیده مقاله:
Background and Aim: Midazolam is among routine agents used for inducing safe sedation. This study was designed to compare the sedative effect of oral administration of midazolam (Elixir vs Vial) in fearful children during dental treatment. Materials and Methods: A randomized double blind clinical trial was conducted in a cross over style on 20 young fearful aged 3-6 years with Frankl behavioral scale of 1. Children were randomly divided into two groups. Group I received 0.5 mg/kg Midazolam Vial and 1 mg/kg Hydroxyzine oral at their first visit and 0.5 mg/kg Midazolam Elixir and 1 mg/kg Hydroxyzine oral in their second visit. In group II, the medication order was reversed. Houpt scale was used to measure the sedation level in both groups. Vital signs of heart rate and SpO2 were recorded during the procedure. Paired t-test, Wilcoxson and McNamara were employed to statistically analyze and compare the collected data between two groups. Results: Based on the collected data, Houpt scale was seemingly improved more after taking elixir compare to the vial, however the difference was not statistically significant (P= 0.393). There was no significant difference between the success rate of the two methods (P= 0.625). All physiologic parameters were within the normal range with no significant difference between two groups and sessions. Conclusion: The level of success between the two groups for sedation was not statistically different and were almost the same. This may indicate a successful use of the vial for oral application in certain cases of compromised cooperation.
منابع مشابه
“Comparative Evaluation of Oral Midazolam, Oral Ketamine And Oral Midazolam-Ketamine Combination As Conscious Sedative Agents in Uncooperative Pediatric Dental Patients”
Conscious Sedation is a technique in which the use of a drug produces a state of depression of central nervous system enabling treatment to be carried out, but during which verbal contact with the patients is maintained throughout the period of sedation. Various drugs have been used as sedative agents in pediatric dentistry to produce conscious sedation such a nitrous oxide, diazepam, midazolam...
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عنوان ژورنال
دوره 29 شماره 2
صفحات 64- 69
تاریخ انتشار 2017-04
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